反应详情

To a solution of (R)-quinuclidin-3-yl 2-(tert-butoxycarbonylamino)-2-(4-fluorophenyl)acetate (C50) (350 mg, 0.92 mmol) in THF (20 ml), was added 37% hydrogen chloride (1.0 ml, 12.2 mmol), and the reaction was stirred at RT for 15 hours. Then a second portion of 37% hydrogen chloride (1.0 ml, 12.2 mmol) was added again, and the reaction was further stirred at RT for 24 hours. Then the volatiles were evaporated under vacuum to obtain (R)-quinuclidin-3-yl 2-amino-2-(4-fluorophenyl)acetate dihydrochloride (325 mg; quantitative yield).

1. stirringthe reaction was further stirred at RT for 24 hours
2. customThen the volatiles were evaporated under vacuum