反应详情

To a solution of (S)—((R)-quinuclidin-3-yl) 2-(tert-butoxycarbonylamino)-3-phenylpropanoate (600 mg, 1.60 mmol) in EtOAc (10 ml), was added portionwise 2-bromo-1-phenylethanone (303 mg, 1.52 mmol). The reaction was stirred at RT for three days. The precipitate was collected by filtration and dried under vacuum to obtain (R)-3-((S)-2-(tert-butoxycarbonylamino)-3-phenylpropanoyloxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane bromide (740 mg, 81% yield).

1. filtrationThe precipitate was collected by filtration
2. customdried under vacuum