反应详情

The compound 1,2-Diaminoanthraquinone (1.19 g, 5 mmol) is dissolved in THF (30 mL), and thionyl chloride (0.15 g, 20 mmol) is then dripped thereinto; triethylamine (TEA, 3 mL) is lastly added thereinto for catalyzation. After being mixed at room temperature for one hour, the mixture is transferred into a container with 200 mL of icy water for crystallization. After filtration, a precipitate is collected and re-crystallized with hot alcohol, so as to obtain the yellow compound NSC745885 with a melting point of 227-228° C., and the production rate is about 74%.

1. additionAfter being mixed at room temperature for one hour
2. customthe mixture is transferred into a container with 200 mL of icy water for crystallization
3. filtrationAfter filtration
4. customa precipitate is collected
5. customre-crystallized with hot alcohol