反应详情

140 mg (430 μmol) (R)-3-methoxy-4-oxo-4-(2-phenyl-benzoxazol-6-yl)-butyric acid are combined at RT with 190 mg (500 μmol) HATU, 200 μl (1424 μmol) TEA and 2 ml DMF. The mixture is stirred for 10 min, then 431 μl (431 μmol) hydrazine 1M in THF are added. The mixture is stirred for a further 2 h at RT, then extracted with DCM and phosphate buffer (pH7). The org. phase is dried and evaporated down. The residue is purified by RP-HPLC.

1. stirringThe mixture is stirred for a further 2 h at RT
2. extractionextracted with DCM and phosphate buffer (pH7)
3. customphase is dried
4. customevaporated down
5. customThe residue is purified by RP-HPLC