反应详情

40 mg (119 μmol) 5-ethyl-6-[2-(4-hydroxy-phenyl)-benzoxazol-6-yl]-4,5-dihydro-2H-pyridazin-3-one, 23.5 mg (142 μmol) 2-(chloromethyl)-pyrimidine, 50 mg (362 μmol) potassium carbonate and 2 ml DMF are together heated to 80° C. for 2.5 h. Then the mixture is extracted with 10% sodium carbonate solution and EA. The org. phase is washed with sat. saline solution, dried on sodium sulphate and then the solv. is totally eliminated i.V. The residue is recrystallised from cyclohexane/EA.

1. extractionThen the mixture is extracted with 10% sodium carbonate solution and EA
2. washphase is washed with sat. saline solution
3. customdried on sodium sulphate
4. customThe residue is recrystallised from cyclohexane/EA