Trifluoroacetic acid → HCID 67464830, compound

HRID 1619954Notes

Reaction equation

HRID 1619954 reaction equation
[CH2:1]([CH:3]1[CH2:8][C:7](=[O:9])[NH:6][N:5]=[C:4]1[C:10]1[CH:33]=[CH:32][C:13]2[N:14]=[C:15]([C:17]3[CH:31]=[CH:30][C:20]([O:21][CH2:22][C:23]([O:25]C(C)(C)C)=[O:24])=[CH:19][CH:18]=3)[O:16][C:12]=2[CH:11]=1)[CH3:2].C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:1]([CH:3]1[CH2:8][C:7](=[O:9])[NH:6][N:5]=[C:4]1[C:10]1[CH:33]=[CH:32][C:13]2[N:14]=[C:15]([C:17]3[CH:31]=[CH:30][C:20]([O:21][CH2:22][C:23]([OH:25])=[O:24])=[CH:19][CH:18]=3)[O:16][C:12]=2[CH:11]=1)[CH3:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 54590844HCID 54590844, compound

Product 1

HCID 67464830HCID 67464830, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

20 mg (44 μmol) tert-butyl {4-[6-(4-ethyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-benzoxazol-2-yl]-phenoxy}-acetate (Example 66), 500 μl TFA and 1 ml DCM are stirred together for 2 h at RT, then the solv. is totally eliminated i.V. and the residue is crystallised from cyclohexane/EA.

Workup

  1. customand the residue is crystallised from cyclohexane/EA

Sources & evidence

ORD record
ord-74f6f455258146cb81bc2ab93a63cfc6
Source dataset
uspto-grants-2014_07
Patent number
US08772323B2

Reaction notes

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