Methyl iodide → HCID 17993492, compound

HRID 1619975Notes

Reaction equation

HRID 1619975 reaction equation
[CH3:1][CH:2]1[CH2:7][C:6](=[O:8])[NH:5][N:4]=[C:3]1[C:9]1[CH:18]=[CH:17][C:12]2[N:13]=[C:14]([S-:16])[O:15][C:11]=2[CH:10]=1.[K].[CH3:20]I>CN(C=O)C>[CH3:1][CH:2]1[C:3]([C:9]2[CH:18]=[CH:17][C:12]3[N:13]=[C:14]([S:16][CH3:20])[O:15][C:11]=3[CH:10]=2)=[N:4][NH:5][C:6](=[O:8])[CH2:7]1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 5462222PotassiumHCID 178429556HCID 178429556, compound

Product 1

HCID 17993492HCID 17993492, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
50 °C

Procedure

85 g (0.284 mol) 6-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-benzoxazol-2-thiolate as potassium salt, 34.3 ml (0.55 mol) methyl iodide and 200 ml DMF are combined and the mixture is stirred for 1 h at 50° C., then the reaction mixture is poured onto ice water. The precipitated solid is suction filtered and washed with water, isopropanol and diethyl ether.

Workup

  1. additionthe reaction mixture is poured onto ice water
  2. filtrationfiltered
  3. washwashed with water, isopropanol and diethyl ether

Sources & evidence

ORD record
ord-caf790354cc44caaa4701c49eeaff8fe
Source dataset
uspto-grants-2014_07
Patent number
US08772323B2

Reaction notes

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