Hydrochloric Acid → HCID 67466045, compound

HRID 1619988Notes

Reaction equation

HRID 1619988 reaction equation
[C:1]([CH:4]1[CH2:6][CH:5]1[C:7]([C:9]1(C(OCC)=O)[CH2:23][CH2:22][C:12]2[N:13]=[C:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[O:15][C:11]=2[CH2:10]1)=[O:8])([OH:3])=[O:2].Cl>O>[C:16]1([C:14]2[O:15][C:11]3[CH2:10][CH:9]([C:7]([CH:5]4[CH2:6][CH:4]4[C:1]([OH:3])=[O:2])=[O:8])[CH2:23][CH2:22][C:12]=3[N:13]=2)[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67466354HCID 67466354, compound

Product 1

HCID 67466045HCID 67466045, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

790 mg (2.06 mmol) ethyl 6-(2-carboxy-cyclopropanecarbonyl)-2-phenyl-4,5,6,7-tetrahydro-benzoxazole-6-carboxylate, 5 ml of 32% hydrochloric acid and 5 ml of water are refluxed together for 6 h. The reaction mixture is extracted with DCM, the org. phase is dried on magnesium sulphate and then the solv. is eliminated by rotary evaporation i.V.

Workup

  1. extractionThe reaction mixture is extracted with DCM
  2. customphase is dried on magnesium sulphate

Sources & evidence

ORD record
ord-583360cfc76a463fb2a6c6c4e90b55f8
Source dataset
uspto-grants-2014_07
Patent number
US08772323B2

Reaction notes

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