Hydrazinecarboxylic acid, ethyl ester → HCID 86689076, compound

HRID 1620007Notes

Reaction equation

HRID 1620007 reaction equation
[OH:1][CH:2]([CH2:20][CH3:21])[C:3]([N:5]1[CH2:10][CH2:9][C:8]2[N:11]=[C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[O:13][C:7]=2[CH2:6]1)=S.[CH2:22]([O:24][C:25]([NH:27][NH2:28])=[O:26])[CH3:23]>C1COCC1.C([O-])(=O)C.[Hg+]>[OH:1][CH:2]([CH2:20][CH3:21])[C:3](=[N:28][NH:27][C:25]([O:24][CH2:22][CH3:23])=[O:26])[N:5]1[CH2:10][CH2:9][C:8]2[N:11]=[C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[O:13][C:7]=2[CH2:6]1

Participants

5

Reactant 2

HCID 20064Hydrazinecarboxylic acid, ethyl esterHCID 86689075HCID 86689075, compound

Product 1

HCID 86689076HCID 86689076, compound

Reagents, catalysts & solvents 2

HCID 61181Mercurous acetateCatalystHCID 8028TetrahydrofuranSolvent

Procedure

185.00 mg (612 μmol) 2-hydroxy-1-(2-phenyl-6,7-dihydro-4H-oxazolo[5,4-c]pyridin-5-yl)-butan-1-thione, 70.00 mg (672 μmol) ethylhydrazinecarboxylate and 200.00 mg (628 μmol) mercury acetate are placed in 10 mL THF and the mixture is stirred for 2 h at RT. The reaction mixture is filtered through silica gel suction and the solvent is eliminated in vacuo.

Workup

  1. filtrationThe reaction mixture is filtered through silica gel suction

Sources & evidence

ORD record
ord-740acdbd5fe54a98adea71d2fa0aa4e9
Source dataset
uspto-grants-2014_07
Patent number
US08772323B2

Reaction notes

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