Hydrochloric Acid → HCID 86689078, compound

HRID 1620015Notes

Reaction equation

HRID 1620015 reaction equation
C[O:2][CH:3](OC)[CH:4]([CH3:30])[O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[O:13][C:14]3[CH:20]=[C:19]([C:21]4[CH:22]([CH2:28][CH3:29])[CH2:23][C:24](=[O:27])[NH:25][N:26]=4)[CH:18]=[CH:17][C:15]=3[N:16]=2)=[CH:8][CH:7]=1.Cl>O1CCOCC1>[CH2:28]([CH:22]1[CH2:23][C:24](=[O:27])[NH:25][N:26]=[C:21]1[C:19]1[CH:18]=[CH:17][C:15]2[N:16]=[C:12]([C:9]3[CH:10]=[CH:11][C:6]([O:5][CH:4]([CH3:30])[CH:3]=[O:2])=[CH:7][CH:8]=3)[O:13][C:14]=2[CH:20]=1)[CH3:29]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 674673256-{2-[4-(2,2-dimethoxy-1-methyl-ethoxy)-phenyl]-benzoxazol-6-yl}-5-ethyl-4,5-dihydro-2H-pyridazin-3-one

Product 1

HCID 86689078HCID 86689078, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

54 mg (74 μmol) 6-{2-[4-(2,2-dimethoxy-1-methyl-ethoxy)-phenyl]-benzoxazol-6-yl}-5-ethyl-4,5-dihydro-2H-pyridazin-3-one, 200 μL (4 mmol/mL; 800 μmol) HCl and 5 ml dioxane are stirred for 40 min at 80° C. Then the mixture is extracted with EA, extracted twice with H2O and then with sat. saline solution. The solv. of the org. phase is eliminated i.V.

Workup

  1. extractionThen the mixture is extracted with EA
  2. extractionextracted twice with H2O

Sources & evidence

ORD record
ord-d1e9e5b572394133a32f5903bb9466be
Source dataset
uspto-grants-2014_07
Patent number
US08772323B2

Reaction notes

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