反应详情

To a solution of 4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-3-(2-methoxypyridin-3-yl)benzonitrile (Preparation 26, 534 mg, 1.35 mmol) in DMSO (10.0 mL) was added potassium carbonate (560 mg, 4.05 mmol) and a 30% aqueous solution of hydrogen peroxide (690 μL, 6.74 mmol). The reaction was stirred at room temperature for 1 hour. Water (50 mL) was added to the reaction mixture resulting in the formation of a white precipitate. The precipitate was filtered, washed with water (50 mL) and dried in vacuo to obtain the title compound as a colourless solid (436 mg, 85%), which was used without further purification in the next step.

1. customresulting in the formation of a white precipitate
2. filtrationThe precipitate was filtered
3. washwashed with water (50 mL)
4. customdried in vacuo