反应详情

To a solution of methyl 4-(4-chlorophenoxy)-2-fluoro-5-(2-methoxypyridin-3-yl)benzoate (Preparation 31, 194 mg, 0.50 mmol) in THF (10 mL) was added aqueous lithium hydroxide solution (1M, 2.51 mL, 2.51 mmol) and the mixture stirred for 72 hours at room temperature under a nitrogen atmosphere. The reaction was then concentrated in vacuo to afford the title compound as a white solid (236 mg, 100%).

1. concentrationThe reaction was then concentrated in vacuo