反应详情

A solution of Example 2C (3.5 g, 12.2 mmol)in dichloromethane (25 mL) and methanol (2.5 mL) was cooled to −78° C. and O3 was bubbled for twenty-five minutes. The reaction was purged with N2 and DMS (5.29 g, 85.4 mmol) was added. The reaction was stirred at room temperature for three hours. The solvent was evaporated in vacuo and the product purified by flash column chromatography (hexanes:ethyl acetate) 100:0 to 50:50) to provide the title compound as an oil.

1. customO3 was bubbled for twenty-five minutes
2. additionwas added
3. customThe solvent was evaporated in vacuo
4. customthe product purified by flash column chromatography (hexanes:ethyl acetate) 100:0 to 50:50)