反应详情

First, 2-amino-6-fluoro-benzoic acid methyl ester (1.00 g, 5.91 mmol) was dissolved in purified CH2Cl2, and after adding DMAP (0.04 g, 0.30 mmol) and (4-fluoro-phenyl)-acetyl chloride (1.22 g, 6.50 mmol) at 0° C., reacted together at normal temperature for 10 hours. After adding cold sodium bicarbonate solution containing ice, the reaction mixture was extracted with CH2Cl2, washed with distilled water, dried with MgSO4, and then concentrated under reduced pressure to obtain crude 2-fluoro-6-[2-(4-fluoro-phenyl)-acetylamino]-benzoic acid methyl ester (1.20 g, 61%) as the solid.

1. customreacted together at normal temperature for 10 hours
2. additioncontaining ice
3. extractionthe reaction mixture was extracted with CH2Cl2
4. washwashed with distilled water
5. dry with materialdried with MgSO4
6. concentrationconcentrated under reduced pressure