反应详情

To a solution of (5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]piperidin-4-yl}methylidene)-4-{[2-(2-hydroxyethoxy)ethyl]amino}-1,3-thiazol-2(5H)-one (4.3 g) in ethyl acetate (40 ml) was added tosylic acid monohydrate (3.11 g), and the mixture was stirred at room temperature for 2 hr. The precipitate was collected by filtration, washed with ethyl acetate, and recrystallized from 2-butanone/heptane to give the title compound (4.4 g).

1. filtrationThe precipitate was collected by filtration
2. washwashed with ethyl acetate
3. customrecrystallized from 2-butanone/heptane