Triethylamine → HCID 178484615, compound

HRID 1620639Notes

Reaction equation

HRID 1620639 reaction equation
Cl.[CH3:2][N:3]([CH3:8])[C:4](=[O:7])[CH2:5][NH2:6].C(N(CC)CC)C.S=[C:17]1[CH2:21][S:20][C:19](=[O:22])[NH:18]1>C(O)C>[CH3:2][N:3]([CH3:8])[C:4](=[O:7])[CH2:5][NH:6][C:17]1[CH2:21][S:20][C:19](=[O:22])[N:18]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 15395954-Sulfanylidene-1,3-thiazolidin-2-oneHCID 20129283N,N-Dimethylglycinamide--hydrogen chloride (1/1)

Product 1

HCID 178484615HCID 178484615, compoundYield 64.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of N,N-dimethylglycinamide hydrochloride (5 g) and triethylamine (5.03 mL) in ethanol (20 mL) was added 4-thioxo-1,3-thiazolidin-2-one (4.81 g), and the mixture was stirred at room temperature for 4 hr. The reaction mixture was concentrated, and the residue was purified by silica gel column chromatography (NH, ethyl acetate/THF) to give the title compound (4.68 g).

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue was purified by silica gel column chromatography (NH, ethyl acetate/THF)

Sources & evidence

ORD record
ord-7c043bb9975b4ca5a3935a496f5eff19
Source dataset
uspto-grants-2014_07
Patent number
US08772277B2

Reaction notes

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