3-Amino-1-propanol → HCID 178518141, compound

HRID 1620719Notes

Reaction equation

HRID 1620719 reaction equation
S=[C:2]1[CH2:6][S:5][C:4](=[O:7])[NH:3]1.[NH2:8][CH2:9][CH2:10][CH2:11][OH:12]>C(O)C>[OH:12][CH2:11][CH2:10][CH2:9][NH:8][C:2]1[CH2:6][S:5][C:4](=[O:7])[N:3]=1

Participants

4

Reactant 2

HCID 90863-Amino-1-propanolHCID 15395954-Sulfanylidene-1,3-thiazolidin-2-one

Product 1

HCID 178518141HCID 178518141, compoundYield 77.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 4-thioxothiazolidin-2-one (2.66 g) in ethanol (50 mL) was added 3-aminopropan-1-ol (1.50 g) at room temperature. The reaction mixture was stirred at room temperature for 4 hr, the solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (NH, methanol/ethyl acetate) to give the title compound (2.70 g).

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customthe residue was purified by silica gel column chromatography (NH, methanol/ethyl acetate)

Sources & evidence

ORD record
ord-06d7b931519a4ee580935bb6927e82c5
Source dataset
uspto-grants-2014_07
Patent number
US08772277B2

Reaction notes

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