Hydrogen chloride-ethyl acetate → HCID 178448897, compound

HRID 1620733Notes

Reaction equation

HRID 1620733 reaction equation
[F:1][C:2]([F:33])([F:32])[C:3]1[CH:27]=[C:26]([C:28]([F:31])([F:30])[F:29])[CH:25]=[CH:24][C:4]=1[CH2:5][N:6]1[CH2:11][CH2:10][CH:9](/[CH:12]=[C:13]2/[C:14]([NH:19][CH:20]([CH3:23])[C:21]#[CH:22])=[N:15][C:16](=[O:18])[S:17]/2)[CH2:8][CH2:7]1.[ClH:34].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:34].[F:33][C:2]([F:1])([F:32])[C:3]1[CH:27]=[C:26]([C:28]([F:30])([F:31])[F:29])[CH:25]=[CH:24][C:4]=1[CH2:5][N:6]1[CH2:7][CH2:8][CH:9](/[CH:12]=[C:13]2/[C:14]([NH:19][CH:20]([CH3:23])[C:21]#[CH:22])=[N:15][C:16](=[O:18])[S:17]/2)[CH2:10][CH2:11]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 178448895HCID 178448895, compound

Product 1

HCID 178448897HCID 178448897, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of (5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]piperidin-4-yl}methylidene)-4-[(1-methylprop-2-yn-1-yl)amino]-1,3-thiazol-2(5H)-one (980 mg) in ethyl acetate (10 mL) was added 4N hydrogen chloride/ethyl acetate (0.50 mL) solution, and the precipitate was collected by filtration to give the title compound (635 mg).

Workup

  1. filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record
ord-7afe5309cd9b4f559ede676fb344185d
Source dataset
uspto-grants-2014_07
Patent number
US08772277B2

Reaction notes

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