Hydrogen chloride-ethyl acetate → HCID 178479699, compound

HRID 1620734Notes

Reaction equation

HRID 1620734 reaction equation
[F:1][C:2]([F:36])([F:35])[C:3]1[CH:30]=[C:29]([C:31]([F:34])([F:33])[F:32])[CH:28]=[CH:27][C:4]=1[CH2:5][N:6]1[CH2:11][CH2:10][CH:9](/[CH:12]=[C:13]2/[C:14]([NH:19][CH2:20][C:21]([NH:23][CH:24]3[CH2:26][CH2:25]3)=[O:22])=[N:15][C:16](=[O:18])[S:17]/2)[CH2:8][CH2:7]1.[ClH:37].C(OCC)(=O)C>C1COCC1>[ClH:37].[F:36][C:2]([F:1])([F:35])[C:3]1[CH:30]=[C:29]([C:31]([F:33])([F:34])[F:32])[CH:28]=[CH:27][C:4]=1[CH2:5][N:6]1[CH2:7][CH2:8][CH:9](/[CH:12]=[C:13]2/[C:14]([NH:19][CH2:20][C:21]([NH:23][CH:24]3[CH2:25][CH2:26]3)=[O:22])=[N:15][C:16](=[O:18])[S:17]/2)[CH2:10][CH2:11]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 178521294HCID 178521294, compound

Product 1

HCID 178479699HCID 178479699, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of N2-[(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]piperidin-4-yl}methylidene)-2-oxo-2,5-dihydro-1,3-thiazol-4-yl]-N-cyclopropylglycinamide (700 mg) in THF (10 mL) was added a solution of 4N hydrogen chloride/ethyl acetate (0.33 mL), and the precipitate was so collected by filtration to give the title compound (301 mg).

Workup

  1. filtrationthe precipitate was so collected by filtration

Sources & evidence

ORD record
ord-7cf296dc758d421cb7977cf9523b814c
Source dataset
uspto-grants-2014_07
Patent number
US08772277B2

Reaction notes

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