反应详情

2 M hydrochloric acid (3.0 mL) is added to a suspension of 3 (0.12 g, 0.33 mmol) in tetrahydrofuran (3.0 mL), and the resulting suspension is warmed to reflux. The reaction becomes homogeneous upon heating. After refluxing for 1.5 h, the reaction is allowed to cool to room temperature, and is then partitioned between diethyl ether and water. The ether layer is washed with water, saturated aqueous sodium bicarbonate, and brine. The ether layer is dried with anhydrous sodium sulfate and concentrated in vacuo. The residue is triturated with ethyl acetate, the solvent is removed under a stream of nitrogen, and the resulting solid is dried in vacuo at 55° C. to give 4 as a light yellow solid.

1. temperaturethe resulting suspension is warmed to reflux
2. temperatureupon heating
3. temperatureAfter refluxing for 1.5 h
4. customis then partitioned between diethyl ether and water
5. washThe ether layer is washed with water, saturated aqueous sodium bicarbonate, and brine
6. dry with materialThe ether layer is dried with anhydrous sodium sulfate
7. concentrationconcentrated in vacuo
8. customThe residue is triturated with ethyl acetate
9. customthe solvent is removed under a stream of nitrogen
10. customthe resulting solid is dried in vacuo at 55° C.