Hydrochloric Acid → HCID 21758136, compound

HRID 1621087Notes

Reaction equation

HRID 1621087 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:4]=[C:3]1[CH2:13][CH2:14][NH:15]C(=O)OC(C)(C)C.[ClH:23]>O1CCOCC1>[ClH:23].[ClH:23].[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:4]=[C:3]1[CH2:13][CH2:14][NH2:15]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 71279224HCID 71279224, compound

Product 1

HCID 21758136HCID 21758136, compoundYield 98.5%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Conditions

Temperature
20 °C

Procedure

To a suspension of tert-butyl 2-(1-methyl-4-phenyl-1H-imidazol-2-yl)ethylcarbamate (831 mg, 2.76 mmol) in dioxane (5 mL) was added HCl in dioxane (4M, 6.89 mL, 27.6 mmol) dropwise. The reaction mixture was stirred at 20° C. for 1.5 h. The crude reaction mixture was concentrated in vacuo. Heptane was added and the suspension was stirred for 30 min and evaporated in vacuo to give the product as white solid (760 mg, 2.72 mmol, 98.5%). MS: M=202.3 (M−2HCl+H)+

Workup

  1. customThe crude reaction mixture
  2. concentrationwas concentrated in vacuo
  3. additionHeptane was added
  4. stirringthe suspension was stirred for 30 min
  5. customevaporated in vacuo

Sources & evidence

ORD record
ord-de8c2f3acdcf4b5680beb2721a20b790
Source dataset
uspto-grants-2014_07
Patent number
US08772510B2

Reaction notes

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