Hydrochloric Acid → HCID 86677479, compound

HRID 1621097Notes

Reaction equation

C(OC([N:8](C(OC(C)(C)C)=O)[CH2:9][CH2:10][C:11]1[N:15]([CH3:16])[N:14]=[C:13]([C:17]2[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=2)[N:12]=1)=O)(C)(C)C.[ClH:30]>>[ClH:30].[ClH:30].[CH3:16][N:15]1[C:11]([CH2:10][CH2:9][NH2:8])=[N:12][C:13]([C:17]2[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=2)=[N:14]1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 71279154HCID 71279154, compound

Product 1

HCID 86677479HCID 86677479, compoundYield 104%

Procedure

5-[2-Bis(tert-butoxycarbonyl)aminoethyl]-1-methyl-3-pyridin-3-yl-[1,2,4]triazole (133 mg, 330 μmol) was suspended in hydrochloric acid (4M solution in dioxane, 2 mL, 8.00 mmol) and the mixture was stirred at r. t. for 1 h. The reaction mixture was evaporated and dried to give the product as colorless solid (118 mg, 342 μmol, 104%) which was used without any further purification for the next step. MS: M=204.2 (M+H)+

Workup

customThe reaction mixture was evaporated
customdried

Sources & evidence

ORD record: ord-f9b8a2106ed244e5af02248b6c897957
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08772510B2

Reaction notes

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