Hydrochloric Acid → HCID 71279109, compound

HRID 1621107Notes

Reaction equation

HRID 1621107 reaction equation
[CH3:1][C:2]([NH:16]C(=O)OC(C)(C)C)([CH3:15])[CH2:3][C:4]1[O:8][N:7]=[C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:5]=1.[ClH:24]>C(OC)(C)(C)C>[ClH:24].[CH3:15][C:2]([NH2:16])([CH3:1])[CH2:3][C:4]1[O:8][N:7]=[C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:5]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 71279106HCID 71279106, compound

Product 1

HCID 71279109HCID 71279109, compoundYield 92.4%

Reagents, catalysts & solvents 1

HCID 15413tert-Butyl methyl etherSolvent

Procedure

A solution of tert-butyl 2-methyl-1-(3-phenyl-1,2,4-oxadiazol-5-yl)propan-2-ylcarbamate (2.72 g, 8.57 mmol) and HCl (4M in dioxane; 21.4 mL, 85.7 mmol) was stirred at 25° C. for 3 h. The resulting white suspension was diluted with tert-butylmethylether (100 mL) and stirred for 1 h. The reaction mixture was filtered and the precipitate was dried in vacuo to give the product as white solid (2.01 g, 7.92 mmol, 92.4%). MS: M=218.1 (M+H−HCl)+

Workup

  1. filtrationThe reaction mixture was filtered
  2. customthe precipitate was dried in vacuo

Sources & evidence

ORD record
ord-9be3e180488d408e8d8363cce0cb3c66
Source dataset
uspto-grants-2014_07
Patent number
US08772510B2

Reaction notes

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