Hydrochloric Acid → HCID 71279189, compound

HRID 1621128Notes

Reaction equation

HRID 1621128 reaction equation
C(OC([N:8](C(OC(C)(C)C)=O)[CH2:9][CH2:10][C:11]1[N:15]([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[N:14]=[C:13]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[N:12]=1)=O)(C)(C)C.C(N1C(CCNC(=O)OC(C)(C)C)=NC(C2C=CC=CC=2)=N1)C1C=CC=CC=1.[ClH:64]>>[ClH:64].[CH2:16]([N:15]1[C:11]([CH2:10][CH2:9][NH2:8])=[N:12][C:13]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[N:14]1)[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 71279138HCID 71279138, compoundHCID 71279185HCID 71279185, compound

Product 1

HCID 71279189HCID 71279189, compound

Procedure

A solution of 5-[2-bis(tert-butoxycarbonyl)aminoethyl]-1-benzyl-3-phenyl-[1,2,4]triazole (103 mg, 215 μmol) and tert-butyl 2-(1-benzyl-3-phenyl-1H-1,2,4-triazol-5-yl)ethylcarbamate (38.5 mg, 102 μmol) in HCl (4M in Dioxane, 3 mL, 12.0 mmol) was stirred at RT for 1 h. The reaction mixture was concentrated in vacuo and the resulting solid was poured on diethyl ether (2.5 mL), filtrated off and washed with little diethyl ether. The obtained white crystals were dried (74 mg, 74%) and used without further purification for the next step.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. additionthe resulting solid was poured on diethyl ether (2.5 mL)
  3. filtrationfiltrated off
  4. washwashed with little diethyl ether
  5. customThe obtained white crystals were dried (74 mg, 74%)
  6. customused without further purification for the next step

Sources & evidence

ORD record
ord-91f6be62c41c4987b1563a48b892f074
Source dataset
uspto-grants-2014_07
Patent number
US08772510B2

Reaction notes

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