Triphenylphosphine → HCID 71279235, compound

HRID 1621130Notes

Reaction equation

HRID 1621130 reaction equation
[N:1]([CH2:4][CH2:5][C:6]1[N:7]=[C:8]([C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][CH:13]=2)[S:9][C:10]=1[CH3:11])=[N+]=[N-].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>O>[CH3:11][C:10]1[S:9][C:8]([C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][CH:13]=2)=[N:7][C:6]=1[CH2:5][CH2:4][NH2:1]

Participants

4

Reactant 2

HCID 11776TriphenylphosphineHCID 71279231HCID 71279231, compound

Product 1

HCID 71279235HCID 71279235, compoundYield 99.7%

Reagents, catalysts & solvents 1

HCID 962WaterCatalyst

Procedure

4-(2-Azidoethyl)-5-methyl-2-p-tolylthiazole (160 mg, 619 μmol), triphenylphosphine polymer bound (270 mg, 803 μmol) and water (2 drops, 8 μL, 444 μmol) were combined at RT to give a brown suspension. The mixture was stirred at RT overnight. The suspension was filtered and the liquid was evaporated to give the product as light yellow oil (151 mg, 617 μmol, 99.7%) which was used without further purification for the next step.

Workup

  1. customwere combined at RT
  2. customto give a brown suspension
  3. filtrationThe suspension was filtered
  4. customthe liquid was evaporated

Sources & evidence

ORD record
ord-fc001a51a4c946099185ea4286a631e8
Source dataset
uspto-grants-2014_07
Patent number
US08772510B2

Reaction notes

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