反应详情

A solution of 1,1-dimethylethyl {(1S)-2-[4-(bromoacetyl)phenyl]-1-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]ethyl}carbamate (6.9 mmol), 3-bromo-2-pyridinamine (8.4 mmol), and sodium bicarbonate (10.4 mmol) in isopropanol (70 mL) were stirred at 80° C. for 18 h. The reaction was then cooled to RT and a precipitate formed which, was filtered, washed with cold hexanes (3×100 mL), and dried to afford the title compound light gray solid (72%). ESMS [M+H]+: 576.2.

1. customa precipitate formed which
2. filtrationwas filtered
3. washwashed with cold hexanes (3×100 mL)
4. customdried