HCID 67022881, compound → HCID 25108974, compound

HRID 1621284Notes

Reaction equation

HRID 1621284 reaction equation
FC(F)(F)C(O)=O.C(OC([N:15]1[CH2:19][C@H:18]([NH:20][C:21]2[CH:22]=[C:23]3[C:28](=[CH:29][CH:30]=2)[CH:27]=[N:26][CH:25]=[CH:24]3)[CH2:17][C@H:16]1[C:31](=[O:41])[NH:32][C:33]1[CH:38]=[CH:37][C:36]([CH2:39][CH3:40])=[CH:35][CH:34]=1)=O)(C)(C)C>Cl.O1CCOCC1>[CH2:39]([C:36]1[CH:35]=[CH:34][C:33]([NH:32][C:31]([C@@H:16]2[CH2:17][C@@H:18]([NH:20][C:21]3[CH:22]=[C:23]4[C:28](=[CH:29][CH:30]=3)[CH:27]=[N:26][CH:25]=[CH:24]4)[CH2:19][NH:15]2)=[O:41])=[CH:38][CH:37]=1)[CH3:40]

Participants

4

Reactant 1

HCID 67022881HCID 67022881, compound

Product 1

HCID 25108974HCID 25108974, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

(2S,4R)-2-(4-Ethyl-phenylcarbamoyl)-4-(isoquinolin-6-ylamino)-pyrrolidine-1-carboxylic acid tert-butyl ester trifluoroacetate was dissolved in 4 N HCl in dioxane and stirred for 2 h at rt. Evaporation gave (2S,4R)-4-(Isoquinolin-6-ylamino)-pyrrolidine-2-carboxylic acid (4-ethyl-phenyl)-amide as the hydrochloride salt. Rt=1.05 min (Method A). Detected mass: 361.2 (M+H+).

Workup

  1. customEvaporation

Sources & evidence

ORD record
ord-8285ff764f18429884c4989e2b5849e4
Source dataset
uspto-grants-2014_07
Patent number
US08772492B2

Reaction notes

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