m-Chloroperbenzoic acid → N-(6-Methoxypyridin-3-YL)-3-(2-methyl-6-(methylsulfinyl)pyrimidin-4-YL)pyrazin-2-amine

HRID 1621510Notes

Reaction equation

HRID 1621510 reaction equation
[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([NH:9][C:10]2[C:15]([C:16]3[CH:21]=[C:20]([S:22][CH3:23])[N:19]=[C:18]([CH3:24])[N:17]=3)=[N:14][CH:13]=[CH:12][N:11]=2)=[CH:5][CH:4]=1.ClC1C=C(C=CC=1)C(OO)=[O:30]>O1CCOCC1>[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([NH:9][C:10]2[C:15]([C:16]3[CH:21]=[C:20]([S:22]([CH3:23])=[O:30])[N:19]=[C:18]([CH3:24])[N:17]=3)=[N:14][CH:13]=[CH:12][N:11]=2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 66599972N-(6-methoxypyridin-3-yl)-3-(2-methyl-6-(methylthio)pyrimidin-4-yl)pyrazin-2-amine

Product 1

HCID 66600383N-(6-Methoxypyridin-3-YL)-3-(2-methyl-6-(methylsulfinyl)pyrimidin-4-YL)pyrazin-2-amine

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A glass microwave reaction vessel was charged with N-(6-methoxypyridin-3-yl)-3-(2-methyl-6-(methylthio)pyrimidin-4-yl)pyrazin-2-amine (11 mg, 0.032 mmol) and 3-chloroperoxybenzoic acid (11.15 mg, 0.065 mmol) in dioxane (1 mL). The reaction mixture was stirred at room temperature for 1 h. The reaction mixture was used for the next step reaction without purification.

Workup

  1. customA glass microwave reaction vessel
  2. customThe reaction mixture was used for the next step reaction without purification

Sources & evidence

ORD record
ord-058a561592bf45d59d99ed44cce620d2
Source dataset
uspto-grants-2014_07
Patent number
US08772480B2

Reaction notes

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