反应详情

The product of Example 7A (2.03 g, 10.38 mmol) was stirred at room temperature in the presence of ammonium acetate (8 g, 103.8 mmol) and NaBH3CN (3.3 g, 51.9 mmol) in methanol (30 mL) for twelve hours at 23° C. The solvent was then evaporated and the residue was dissolved in dichloromethane; washed with water, NaHCO3 solution, and brine; and dried (Na2SO4). After filtration and evaporation of the solvent, the amine was used without further purification.

1. customThe solvent was then evaporated
2. dissolutionthe residue was dissolved in dichloromethane
3. washwashed with water, NaHCO3 solution, and brine
4. dry with materialand dried (Na2SO4)
5. filtrationAfter filtration and evaporation of the solvent
6. customthe amine was used without further purification