Hydrazine hydrate (1:1) → HCID 53403344, compound

HRID 1622219Notes

Reaction equation

HRID 1622219 reaction equation
C[O:2][C:3]([C:5]1[CH:13]=[C:12]2[C:8]([CH:9]=[CH:10][N:11]2[CH3:14])=[CH:7][CH:6]=1)=O.O.[NH2:16][NH2:17]>CO>[CH3:14][N:11]1[C:12]2[C:8](=[CH:7][CH:6]=[C:5]([C:3]([NH:16][NH2:17])=[O:2])[CH:13]=2)[CH:9]=[CH:10]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 639843Methyl N-methylindole-6-carboxylate

Product 1

HCID 53403344HCID 53403344, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 1-methyl-1H-indole-6-carboxylic acid methyl ester (3.2 g, 16.1 mmol), hydrazine monohydrate (8.5 g, 169 mmol) and methanol (50 ml) was stirred reflux for 15 h. The mixture was evaporated, water was added and the product was isolated by extraction with chloroform, followed by evaporation.

Workup

  1. temperaturereflux for 15 h
  2. customThe mixture was evaporated
  3. additionwater was added
  4. customthe product was isolated by extraction with chloroform
  5. customfollowed by evaporation

Sources & evidence

ORD record
ord-ae8a9882e56440a585900b0b380268f3
Source dataset
uspto-grants-2014_07
Patent number
US08778928B2

Reaction notes

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