Methanol → HCID 86656266, compound

HRID 1622325Notes

Reaction equation

HRID 1622325 reaction equation
[C:1]([N:9]1[CH2:14][CH2:13][N:12]([C:15]([O:17]C(C)(C)C)=[O:16])[CH2:11][CH2:10]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CO.C(Cl)(Cl)[Cl:25]>O1CCOCC1>[ClH:25].[C:1]([N:9]1[CH2:10][CH2:11][N:12]([C:15]([O-:17])=[O:16])[CH2:13][CH2:14]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

6

Reactant 3

HCID 887MethanolHCID 6212ChloroformHCID 185197561-Piperazinecarboxylic acid, 4-benzoyl-, 1,1-diMethylethyl ester

Product 2

HCID 313Hydrochloric AcidHCID 86656266HCID 86656266, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

General procedure B was followed using tert-butyl 4-benzoylpiperazine-1-carboxylate 9 (75 mg, 0.26 mmol), MeOH (2 mL) and a 4 M solution of hydrogen chloride in 1,4-dioxane (2 mL) to furnish the title compound as a colourless oil (47 mg, 96%), umax (CHCl3)/cm−1 3015, 2954, 1622, 1435, 1290, 1136, 1018; m/z (ESI) C11H15N2O requires 191.1179, found [M+H]+ 191.1179.

Sources & evidence

ORD record
ord-3c9adf21c5944c05a736a844dcad0743
Source dataset
uspto-grants-2014_07
Patent number
US08778925B2

Reaction notes

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