反应详情

General procedure C was followed using 3,5-dibromo-4-chloropyridine (71 mg, 0.26 mmol), 3-cyanopyrrolidine (25 mg, 0.26 mmol), NMP (3 mL) and triethylamine (72 μL, 0.52 mmol). The crude product was purified by flash column chromatography on silica gel (CH2Cl2, MeOH, 99:1) to furnish the title compound E22 as a white solid (9 mg, 10%), m.p. 159-161° C.; umax (CHCl3)/cm−1 3022, 3008, 1678, 1591, 1446, 1235; m/z (ESI) C10H12Br2N3O requires 347.9342, found [M+H]+ 347.9339.

1. customThe crude product was purified by flash column chromatography on silica gel (CH2Cl2, MeOH, 99:1)