反应详情

General procedure C was followed using 3,5-dibromo-4-chloropyridine 18 (50 mg, 0.18 mmol), isonipecotamide (24 mg, 0.18 mmol), NMP (2 mL) and triethylamine (51 μL, 0.37 mmol). The crude product was purified by preparative tlc on silica gel (CH2Cl2, MeOH, 9:1) to furnish the title compound as a pale yellow solid (29 mg, 43%), m.p. 158-160° C.; umax (CHCl3)/cm−1 3053, 2985, 1687, 1591; m/z (ESI) C11H14Br2N3O requires 361.9498 found [M+H]+ 361.9500.

1. customThe crude product was purified by preparative tlc on silica gel (CH2Cl2, MeOH, 9:1)