反应详情

温度

50 °C

Platinum(IV) oxide (30 mg) was added to a solution of 9-(6-methoxynaphthalen-2-yl)-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide (218 mg) in THF (dry) (75 ml) and MeOH (75 ml) and the mixture was stirred at room temperature under hydrogen overnight and at 50° C. overnight. Activated carbon was added and the insoluble solid was removed by filtration through NH-silica gel/Celite pad (eluted with EtOAc). The filtrate was concentrated and the residue was crystallized from MeCN-THF/IPE to give the title compound (153 mg) as colorless crystals.

1. additionActivated carbon was added
2. customthe insoluble solid was removed by filtration through NH-silica gel/Celite pad (eluted with EtOAc)
3. concentrationThe filtrate was concentrated
4. customthe residue was crystallized from MeCN-THF/IPE