反应详情

温度

130 °C

Copper(I) iodide (39.2 mg) was added to a mixture of picolinic acid (25.4 mg), 4-(2-aminopyridin-3-yl)phenol (206 mg), tripotassium phosphate (656 mg), 1-bromo-3-(1,1-difluoroethyl)benzene (239 mg) and DMSO (3 ml). The mixture was stirred at 130° C. under nitrogen for 10 hr. The insoluble solid was removed by filtration through silica gel/Celite pad (eluted with EtOAc). Silica-gel was added to the filtrate and the volatiles were removed in vacuo. The mixture supported on silica-gel was purified by column chromatography (NH-silica gel, eluted with EtOAc in hexane) to give the title compound (165 mg) as a yellow amorphous solid.

1. customThe insoluble solid was removed by filtration through silica gel/Celite pad (eluted with EtOAc)
2. additionSilica-gel was added to the filtrate
3. customthe volatiles were removed in vacuo
4. customwas purified by column chromatography (NH-silica gel, eluted with EtOAc in hexane)