1,4-Dioxane hydrochloride → HCID 66616818, compound

HRID 1622963Notes

Reaction equation

HRID 1622963 reaction equation
C(OC([NH:8][C:9]([CH3:19])([C:11]([O:13][CH:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1)=[O:12])[CH3:10])=O)(C)(C)C.[ClH:20].O1CCOCC1>C1COCC1>[ClH:20].[CH3:19][C:9]([C:11]([O:13][CH:14]1[CH2:15][CH2:16][CH2:17][CH2:18]1)=[O:12])([CH3:10])[NH2:8]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 59622363HCID 59622363, compound

Product 1

HCID 66616818HCID 66616818, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Cyclopentyl N-(tert-butoxycarbonyl)-2-methylalaninate (0.254 g, 0.93 mmol) was dissolved in THF (5 ml) and treated with 4M HCl/dioxane (2 ml) and the reaction mixture was stirred at RT for 24 hours. The crude mixture was concentrated under reduced pressure and triturated with Et2O to give a white precipitate. This was further washed with Et2O to give the desired product as a white powder (0.16 g, 82% yield).

Workup

  1. concentrationThe crude mixture was concentrated under reduced pressure
  2. customtriturated with Et2O
  3. customto give a white precipitate
  4. washThis was further washed with Et2O

Sources & evidence

ORD record
ord-acdd706dc46c46869ebc6dbdabacd19c
Source dataset
uspto-grants-2014_07
Patent number
US08778953B2

Reaction notes

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