HCID 69000656, compound → HCID 69507300, compound

HRID 1623126Notes

Reaction equation

HRID 1623126 reaction equation
[CH3:1][C:2]1[N:7]2[N:8]=[N:9][N:10]=[C:6]2[C:5]([N+:11]([O-])=O)=[C:4]([NH:14][CH2:15][CH2:16][CH2:17][CH2:18][OH:19])[C:3]=1[CH3:20]>[Pt].C(#N)C>[NH2:11][C:5]1[C:6]2[N:7]([N:8]=[N:9][N:10]=2)[C:2]([CH3:1])=[C:3]([CH3:20])[C:4]=1[NH:14][CH2:15][CH2:16][CH2:17][CH2:18][OH:19]

Participants

4

Reactant 1

HCID 69000656HCID 69000656, compound

Product 1

HCID 69507300HCID 69507300, compound

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 6342AcetonitrileSolvent

Procedure

Crude 4-[(5,6-dimethyl-8-nitrotetraazolo[1,5-a]pyridin-7-yl)amino]butan-1-ol was combined in a pressure vessel with catalyst (1.3 g of 5% platinum on carbon), and acetonitrile (222 mL). The reaction mixture was placed under hydrogen pressure (30 psi, 2.1×105 Pa) for 3 hours, filtered through a layer of CELITE filter aid, and the filter cake was washed with methanol. The filtrate was concentrated under reduced pressure to provide 11.15 g of 4-[(8-amino-5,6-dimethyl-tetrazolo[1,5-a]pyridin-7-yl)amino]butan-1-ol.

Workup

  1. customfor 3 hours
  2. filtrationfiltered through a layer of CELITE
  3. filtrationfilter aid
  4. washthe filter cake was washed with methanol
  5. concentrationThe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-58956164b514454383d61669aab58a7b
Source dataset
uspto-grants-2014_07
Patent number
US08778963B2

Reaction notes

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