1-Chloro-4-iodobenzene → HCID 51033660, compound

HRID 1623448Notes

Reaction equation

HRID 1623448 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5](I)=[CH:4][CH:3]=1.[CH3:9][O:10][C:11](=[O:37])[C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([CH2:18][N:19]([C:30]2[CH:35]=[CH:34][C:33]([F:36])=[CH:32][CH:31]=2)[C:20](=[O:29])[C:21]#[C:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:13]=1>>[CH3:9][O:10][C:11](=[O:37])[C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([CH2:18][N:19]2[C:30]3[C:31](=[CH:32][C:33]([F:36])=[CH:34][CH:35]=3)/[C:21](=[C:22](\[C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=3)/[C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)/[C:20]2=[O:29])[CH:13]=1

Participants

3

Reactant 2

HCID 125101-Chloro-4-iodobenzeneHCID 67036372HCID 67036372, compound

Product 1

HCID 51033660HCID 51033660, compound

Procedure

The title compound was prepared in analogy to Example 5 starting from 1-chloro-4-iodo-benzene (commercially available) and 3-{[(4-fluoro-phenyl)-(3-phenyl-propynoyl)-amino]-methyl}-benzoic acid methyl ester. 1H NMR (300 Hz, CDCl3): δppm 3.91 (s, 3H), 4.94 (s, 2H), 6.25 (dd, 1H), 6.54 (dd, 2H), 6.75-6.80 (m, 1H), 7.10 (d, 2H), 7.33-7.54 (m, 8H), 7.94 (d, 1H), 7.98 (s, 1H).

Sources & evidence

ORD record
ord-50e5e7c0e11249949399125a25757b3a
Source dataset
uspto-grants-2014_07
Patent number
US08778973B2

Reaction notes

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