1-Chloro-4-iodobenzene → HCID 58201655, compound

HRID 1623459Notes

Reaction equation

HRID 1623459 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5](I)=[CH:4][CH:3]=1.[CH3:9][O:10][C:11](=[O:38])[C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([CH2:18][N:19]([C:30]2[CH:35]=[CH:34][C:33]([F:36])=[CH:32][C:31]=2[Cl:37])[C:20](=[O:29])[C:21]#[C:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:13]=1>>[CH3:9][O:10][C:11](=[O:38])[C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([CH2:18][N:19]2[C:30]3[C:35](=[CH:34][C:33]([F:36])=[CH:32][C:31]=3[Cl:37])/[C:21](=[C:22](\[C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=3)/[C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)/[C:20]2=[O:29])[CH:13]=1

Participants

3

Reactant 2

HCID 125101-Chloro-4-iodobenzeneHCID 67036281HCID 67036281, compound

Product 1

HCID 58201655HCID 58201655, compound

Procedure

The title compound was prepared in analogy to Example 5 starting from 1-chloro-4-iodo-benzene (commercially available) and 3-{[(2-chloro-4-fluoro-phenyl)-(3-phenyl-propynoyl)-amino]-methyl}-benzoic acid methyl ester. 1H NMR (300 Hz, CDCl3): δppm 3.90 (s, 3H), 5.38 (s, 2H), 6.01 (dd, 1H), 6.80 (dd, 1H), 7.27-7.40 (m, 9H), 7.45-7.50 (m, 3H), 7.92 (m, 2H).

Sources & evidence

ORD record
ord-8be25276a2b5478683c4133d4bbd2ec6
Source dataset
uspto-grants-2014_07
Patent number
US08778973B2

Reaction notes

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