反应详情

温度

20 °C

Solid potassium carbonate (2.76 g, 20 mmol) was added to a solution of 5-bromo-2-hydroxybenzoic acid (1.74 g, 8 mmol) in acetone (20 ml) and the reaction mixture was stirred at 20° C. for 10 mins. (Bromomethyl)benzene (3.42 g, 20 mmol) was added dropwise. The reaction mixture was stirred at 71° C. for 10 h. After cooling to room temperature, the mixture was filtered and the filtrate was concentrated to give a colourless oil. The crude product was purified on a silica gel column, eluting with hexane:ethyl acetate (100:5) to yield the title compound as a white solid. 3 g.

1. stirringThe reaction mixture was stirred at 71° C. for 10 h
2. temperatureAfter cooling to room temperature
3. filtrationthe mixture was filtered
4. concentrationthe filtrate was concentrated
5. customto give a colourless oil
6. customThe crude product was purified on a silica gel column
7. washeluting with hexane:ethyl acetate (100:5)