反应详情

Neat (bromomethyl)benzene (17.10 g, 100 mmol) was added to a stirred suspension of 5-bromo-2-hydroxybenzoic acid (8.68 g, 40.0 mmol) and potassium carbonate (13.82 g, 100 mmol) in acetone (150 ml) at 20° C. over 1 min. The reaction mixture was refluxed overnight. After filtration, the filtrate was evaporated to yield the title compound as an oil which was used in the next step without further purification. 15 g.

1. temperatureThe reaction mixture was refluxed overnight
2. filtrationAfter filtration
3. customthe filtrate was evaporated