反应详情

温度

70 °C

(Bromomethyl)benzene (34.2 ml, 288 mmol) was added over 5 minutes to a stirred suspension of 5-bromo-2-hydroxybenzoic acid (28.4 g, 131 mmol) and potassium carbonate (45.2 g, 327 mmol) in acetone (300 ml) in air at room temperature. The reaction mixture was stirred at 70° C. overnight. After filtering, the filtrate was evaporated to give a light yellow oil, dried in a vacuum to give yellow solid, which was washed by petroleum ether (300 ml×2), filtered and dried in vacuum to yield the title compound as a white solid. 48.2 g.

1. filtrationAfter filtering
2. customthe filtrate was evaporated
3. customto give a light yellow oil
4. customdried in a vacuum
5. customto give yellow solid, which
6. washwas washed by petroleum ether (300 ml×2)
7. filtrationfiltered
8. customdried in vacuum