Lithium Hydroxide → HCID 22662041, compound

HRID 1623640Notes

Reaction equation

HRID 1623640 reaction equation
[OH-].[Li+].[F:3][C:4]1[CH:5]=[CH:6][C:7]([O:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[C:8]([CH:19]=1)[C:9]([O:11]CC1C=CC=CC=1)=[O:10]>O.C1COCC1>[F:3][C:4]1[CH:5]=[CH:6][C:7]([O:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[C:8]([CH:19]=1)[C:9]([OH:11])=[O:10]

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 53694565HCID 53694565, compound

Product 1

HCID 22662041HCID 22662041, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of lithium hydroxide (71.9 mg, 3.00 mmol) in water (12 ml) was added to a stirred solution of phenylmethyl 5-fluoro-2-[(phenylmethyl)oxy]benzoate (may be prepared as described in Description 19, 336 mg, 1 mmol) in THF (3 ml). The reaction mixture was stirred at room temperature overnight. The THF was removed, the mixture was adjusted to pH 7 with 2N HCl. The mixture was filtered and the residue was dried to yield the title compound as a white solid. 180 mg.

Workup

  1. customThe THF was removed
  2. filtrationThe mixture was filtered
  3. customthe residue was dried

Sources & evidence

ORD record
ord-c5980c3f87d2414cb76a45b1909ccb4b
Source dataset
uspto-grants-2014_07
Patent number
US08778939B2

Reaction notes

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