反应详情

Lithium hydroxide (0.43 g, 18.14 mmol) was added to a solution of (4-fluorophenyl)methyl 5-bromo-2-{[(4-fluorophenyl)methyl]oxy}benzoate (may be prepared as described in Description 86) (2.62 g, 6.05 mmol) in water (5 ml) and tetrahydrofuran (20 ml). The mixture was stirred overnight and the solvent removed in vacuo. The residue was redissolved in water (30 ml) and acidified to pH=2 using 1N HCl and then extracted with ethyl acetate (3×25 ml). The combined organic layers were dried (MgSO4) and the solvent removed in vacuo to yield the titled compound as a white solid. 1.97 g.

1. customthe solvent removed in vacuo
2. dissolutionThe residue was redissolved in water (30 ml)
3. extractionextracted with ethyl acetate (3×25 ml)
4. dry with materialThe combined organic layers were dried (MgSO4)
5. customthe solvent removed in vacuo