反应详情

To a solution of (3,4-difluorophenyl)methyl 2-{[(3,4-difluorophenyl)methyl]oxy}-5-formylbenzoate (may be prepared by Description 100; 7 g, 16.73 mmol) in tetrahydrofuran (50 ml) was added lithium hydroxide (1.202 g, 50.2 mmol) followed by methanol (12.50 ml) and water (12.5 ml). The mixture was stirred at room temperature overnight. The mixture was then evaporated under reduced pressure to one third volume. The mixture was diluted with water (50 ml) and acidified to pH=1 using 2M aqueous HCl. The solid formed was filtered off, washed with water and air dried under vacuum to give a white solid. 4.85 g.

1. customThe mixture was then evaporated under reduced pressure to one third volume
2. additionThe mixture was diluted with water (50 ml)
3. customThe solid formed
4. filtrationwas filtered off
5. washwashed with water and air
6. customdried under vacuum
7. customto give a white solid