反应详情

To a solution of methyl 2-{[(4-fluorophenyl)methyl]oxy}-5-{1-[2-(4-morpholinyl)ethyl]-1H-pyrazol-4-yl}benzoate (may be prepared as described in Description 113; 372 mg, 0.85 mmol) in tetrahydrofuran (25 ml) was added lithium hydroxide (60.8 mg, 2.54 mmol), water (5 ml) and the mixture was refluxed for 4 hours. The mixture was evaporated under reduced pressure on a buchi. The residue was taken up into water (10 ml) and acidified using 2M aqueous HCl to pH 1. The solid formed was filtered, washed with water and dried in air under vacuum to yield the title compound as a light brown solid. 170 mg.

1. temperaturethe mixture was refluxed for 4 hours
2. customThe mixture was evaporated under reduced pressure on a buchi
3. customThe solid formed
4. filtrationwas filtered
5. washwashed with water
6. customdried in air under vacuum