Lithium Hydroxide → HCID 67108246, compound

HRID 1623739Notes

Reaction equation

HRID 1623739 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][O:9][C:10]2[CH:26]=[CH:25][C:24]([C:27]3[CH:28]=[N:29][N:30]([CH3:32])[CH:31]=3)=[CH:23][C:11]=2[C:12]([O:14]CC2C=CC(F)=CC=2)=[O:13])=[CH:4][CH:3]=1.[Li+].[OH-]>O1CCCC1.O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][O:9][C:10]2[CH:26]=[CH:25][C:24]([C:27]3[CH:28]=[N:29][N:30]([CH3:32])[CH:31]=3)=[CH:23][C:11]=2[C:12]([OH:14])=[O:13])=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 68108578(4-Fluorophenyl)methyl 2-{[(4-fluorophenyl)methyl]oxy}-5-(1-methyl-1H-pyrazol-4-yl)benzoate

Product 1

HCID 67108246HCID 67108246, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

(4-Fluorophenyl)methyl 2-{[(4-fluorophenyl)methyl]oxy}-5-(1-methyl-1H-pyrazol-4-yl)benzoate (may be prepared as described in Description 120; 360 mg, 0.83 mmol) was dissolved in tetrahydrofuran (20 ml) and water (5 ml). Then LiOH (99 mg, 4.14 mmol) was added. The resultant mixture was stirred at room temperature for 16 hours. The solvent was removed. The residue was dissolved in water (20 ml). The solution was acidified by 1N HCl to pH<5. The precipitate was filtered, washed with ether, and dried in vacuo to yield the title compound as a white solid. 260 mg.

Workup

  1. customThe solvent was removed
  2. dissolutionThe residue was dissolved in water (20 ml)
  3. filtrationThe precipitate was filtered
  4. washwashed with ether
  5. customdried in vacuo

Sources & evidence

ORD record
ord-6e9c8473e40d49ecba882ed25cbfe1e4
Source dataset
uspto-grants-2014_07
Patent number
US08778939B2

Reaction notes

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