1,2-Dichloroethane → HCID 69937057, compound

HRID 1623872Notes

Reaction equation

HRID 1623872 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][O:9][C:10]2[CH:18]=[CH:17][C:16]([C:19]3[CH:20]=[N:21][N:22]([CH3:24])[CH:23]=3)=[CH:15][C:11]=2[C:12](O)=[O:13])=[CH:4][CH:3]=1.CC1C(N)=CON=1.[CH:32]1C=C[C:35]2[N:40]([OH:41])N=[N:38][C:36]=2[CH:37]=1.C(Cl)CCl>CN(C)C=O.O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][O:9][C:10]2[CH:18]=[CH:17][C:16]([C:19]3[CH:20]=[N:21][N:22]([CH3:24])[CH:23]=3)=[CH:15][C:11]=2[C:12]([NH:38][C:36]2[CH:35]=[N:40][O:41][C:37]=2[CH3:32])=[O:13])=[CH:6][CH:7]=1

Participants

7

Reactant 4

HCID 111,2-DichloroethaneHCID 757711-HydroxybenzotriazoleHCID 138042843-Methyl-1,2-oxazol-4-amineHCID 67108246HCID 67108246, compound

Product 1

HCID 69937057HCID 69937057, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

A mixture of 2-{[(4-fluorophenyl)methyl]oxy}-5-(1-methyl-1H-pyrazol-4-yl)benzoic acid (may be prepared as described in Description 121; 80 mg, 0.25 mmol), 3-methylisoxazol-4-amine (49.5 mg, 0.37 mmol), HOBT (56.3 mg, 0.37 mmol) and EDC (70.5 mg, 0.37 mmol) in N,N-dimethylformamide (2 ml) was stirred at room temperature for 16 hours. Water (50 ml) was added. A white precipitate was filtered, washed with ethyl acetate, and dried in vacuo to yield the title compound as a white solid. 54 mg,

Workup

  1. filtrationA white precipitate was filtered
  2. washwashed with ethyl acetate
  3. customdried in vacuo

Sources & evidence

ORD record
ord-3c699de1710c4b879610c886cb1a5390
Source dataset
uspto-grants-2014_07
Patent number
US08778939B2

Reaction notes

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