Lithium hydroxide, monohydrate → HCID 68182397, compound

HRID 1623939Notes

Reaction equation

HRID 1623939 reaction equation
[O:1]1[CH2:6][CH2:5][CH:4]([CH2:7][N:8]2[C:15]3[CH:14]4[CH2:16][CH:13]4[CH2:12][C:11]=3[C:10]([C:17]([O:19]CC)=[O:18])=[N:9]2)[CH2:3][CH2:2]1.O.[OH-].[Li+]>C1COCC1.O>[O:1]1[CH2:6][CH2:5][CH:4]([CH2:7][N:8]2[C:15]3[C@@H:14]4[CH2:16][C@@H:13]4[CH2:12][C:11]=3[C:10]([C:17]([OH:19])=[O:18])=[N:9]2)[CH2:3][CH2:2]1

Participants

5

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 68182543HCID 68182543, compound

Product 1

HCID 68182397HCID 68182397, compoundYield 100.3%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
45 °C

Procedure

Ethyl 2-((tetrahydro-2H-pyran-4-yl)methyl)-1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylate (127 mg, 0.437 mmol) was dissolved in THF (4.00 mL) and H2O (4.00 mL). Lithium hydroxide hydrate (55.1 mg, 1.312 mmol) was added and the reaction was stirred at 45° C. for 1.5 h. The organic solvent was removed under reduced pressure to give the title compound (115 mg) as a brown solid. LCMS m/z=263.2 [M+H]+.

Workup

  1. customThe organic solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-b048e62972284bf4a65baafdcbf987ca
Source dataset
uspto-grants-2014_07
Patent number
US08778950B2

Reaction notes

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