Lithium Hydroxide → HCID 68182377, compound

HRID 1623940Notes

Reaction equation

HRID 1623940 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH:7]2[C@H:9]3[CH2:10][C:11]4[C:12]([C:16]([O:18]CC)=[O:17])=[N:13][NH:14][C:15]=4[C@@H:8]23)=[CH:3][CH:2]=1.[Li+].[OH-]>C1COCC1.O>[N:1]1[CH:6]=[CH:5][C:4]([CH:7]2[C@H:9]3[CH2:10][C:11]4[C:12]([C:16]([OH:18])=[O:17])=[N:13][NH:14][C:15]=4[C@@H:8]23)=[CH:3][CH:2]=1

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 86669680HCID 86669680, compound

Product 1

HCID 68182377HCID 68182377, compoundYield 147.9%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

Ethyl (1aR,5aR)-1-(pyridin-4-yl)-1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylate (357 mg, 1.326 mmol) was taken up in THF (4.00 mL) and H2O (4.00 mL). LiOH (95 mg, 3.98 mmol) was added and the reaction was stirred at room temperature for 1.5 h. The organic solvent was removed under reduced pressure to give the title compound (473 mg) as a brown solid. LCMS m/z=242.3 [M+H]+.

Workup

  1. customThe organic solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-5156a5b3bfbc4f808f0e15faf17e183e
Source dataset
uspto-grants-2014_07
Patent number
US08778950B2

Reaction notes

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